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In vitro platelet production

Megakaryocytes constitute ≈0.05% of the cell population in human bone marrow. Bone marrow explants are a reliable tool to study proplatelet formation.

A
Bone marrow explant of WT mouse
B
Bone marrow explant of WT mouse

Bone marrow explant of WT mouse. Proplatelet formation (A) DIC (B) actin (green) CD42c (red) nuclei in blue.

Haematology Research Group

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